Endocrine Abstracts

Introduction: Autoimmune thyroid disease is a multifactorial disorder, which has been linked to the exposure of certain environmental factors.Aims and Objectives: To investigate whether thyroid autoimmunity (TAI) is significantly associated with identifiable and potentially modifiable environmental factors in Maltese individuals.Materials and Methods: A case-control observational study was conducted among 324 Maltese ...

Introduction: Autoimmune thyroid disease is a multifactorial disorder, which has been linked to the exposure of certain environmental factors.Aims and Objectives: To investigate whether thyroid autoimmunity (TAI) is significantly associated with identifiable and potentially modifiable environmental factors in Maltese individuals.Materials and Methods: A case-control observational study was conducted among 324 Maltese ...

Introduction: Women with Turner syndrome (TS) have an increased risk of diabetes mellitus (DM) the pathogenesis of which is not well understood. International guidelines for TS recommend oral glucose tolerance tests (OGTT) but the utility of this test has not been determined. We sought to establish the rate of IGT and DM and characterise the DM-phenotype in adult women with TS.Methods: We performed OGTTs in 37 adults with TS and obtained an additional fa...

Introduction: Thyroid nodules can be detected in 50 to 60% of healthy individuals, particularly in the elderly and females. An increase in differentiated thyroid cancer has been noted over the years, especially papillary thyroid cancer.Objectives: To assess different approaches to management and histological nature of thyroid nodules in Malta, as well as to evaluate the association of ultrasound characteristics with biochemical and histological features....

Case history: A 14.5-year-old girl was brought forward by her mother to the paediatric endocrine clinic in view of virilised genitalia, absent breast development and primary amenorrhoea. Her genital appearance had changed gradually throughout childhood though she never disclosed this to her parents. She was otherwise healthy with no significant family history of note. On examination, she had fused labioscrotal folds containing 10–12 ml testis. There was no obvious vaginal...

Background: Ages at first date and sexual encounter have been observed to be delayed in women with Turner’s syndrome (TS), with late presentation and delayed puberty induction being the main culprits. There is no equivalent data in women with premature ovarian insufficiency (POI).Objectives: We sought to assess whether age at start of oestrogen replacement therapy (ERT) and amenorrhoea status affected the age at first relationship and sexual experie...

ObjectivePrevious studies have documented poor fertility results in women with hypopituitarism (HP) both in terms of pregnancy rates and outcomes. We aimed to assess ovulation induction (OI) and pregnancy outcomes in women with HP compared to women with hypogonadotrophic hypogonadism (HH) treated at University College London Hospitals.DesignA retrospective study.Patients<p class="ab...